After leaving Swallow Falls due to a disastrous food storm he caused, Flint Lockwood joins Live Corp Company, founded by his idol Chester V, where brilliant inventors are busy studying and developing new methods to improve human life. But when the young inventor discovers that his famous invention, a machine that turns water into food, is still working and creating strange "foodimals", he returns to the island to battle hungry tacodiles, shrimpanzees, hippopotatomuses, cheesepiders, and other foodimals to save the world.